Gulf War Veterans 90-91 Need Help –
Calls for National Collaboration to all Scientist, Researchers, Universities and Government Agencies
Gulf War Veterans both deployed and some that were non-deployed still seek complete and thorough answers. We will not leave any behind!
The government may have missed one part of the story. Why in some units that had some sent into theater in Operation Desert Storm and some that did not go into theater do we have illnesses in both groups? This is indeed a huge unanswered question!
We need to listen closely to our veterans. The illnesses after the gulf war of 1990-91 are complex and may be in the end found to have several subgroups.
The questions are: Did unknown vaccine problems exist? Was it a vaccine issue of one vaccine or a genetic problem unknown of prior to 1990? Was the illness like a snowball express of the body reacting to vaccine and then further damaged by other exposures in theater?
Was it a vaccine problem for the nondeployed or was it something else like cross contamination with equipment returning from the Gulf War that was not sterilized? We did have nondeployed that were on duty cleaning gas masks, servicing vehicles ie trucks, tanks, planes, and multiple other means of cross exposure and contamination.
If we are truly going to learn from this horrible post war illness situation with the largest post war casuality and mortality figures ever we need to answer every question beyond a doubt!
While the government may try to limit compensation and do damage control when our veterans need help, scientist and researchers need to truly take the high ground. All need to listen to our veterans and adhere to a high road of truth and dedication that matches the veterans’ sacrifices. WE must not betray or let friendly fire damage one more veteran further.
In furthering this discussion, the writer shares this article below at end of this discussion from Dr. INCAO that highlights one area of concern and would answer maybe part of one question of the ones ill that did not deploy in 1990 and up to this date currently.
It is up to researchers to consider a subgroup of veterans nondeployed but ill. It is up to the VA not to ignore the nondeployed that have similar presentation of illnesses. It is up to the Senators and Representatives in DC to get answers for the veterans in all subgroups, to provide oversight into the research, compensation, health care, to provide laws that provide them equal access to compensation, and to provide adequate funds for compensation for each veteran affected. The funding of compensation must be complete enough that veterans do not end up in a paper battle of who will get compensated and who or which war or era will get the compensation needed for each veteran affected.
It is up to the administration, our president and Commander in Chief to have the right, talented and motivated people on his staff at the White House and in every agency to get the best help and answers for the veterans. It is one thing to say something in a campaign, to say something in platforms, to say something in policy,
to get it into action that counts takes the full team. If you don’t have the right people at each level the bucket is going to leak and defeat your overall goal!
It is up to the veteran to keep asking the questions, to keep demanding answers and action, to not forget your fellow veterans, to not play politics for your own gain, to recognize if you do not have the requirements ie background to fully function in a given environment to find the right ones to fit and fight to make the fit right, to open the door for more veterans with input to be allowed into the table, to respect that each individual brings a part or a different dimension or talent to the table that is needed, to not have friendly fire or to be a leap frog in the game of politics and control. Leap frogs end up in skillets and served up as frog legs. In the military there was time to check and clear your weapons, truly debrief, write the lessons learned and to have full battlefield awareness. That time is now overdue.
How Vaccinations Work
PHILIP F. INCAO, M.D.
In order to use vaccinations wisely, we need to understand exactly how they work. Until recently, the “mechanism of action” of vaccinations was always understood to be simply that they cause an increase in antibody levels (titers) against a specific disease antigen (bacterium or virus), thus preventing “infection” with that bacterial or viral antigen.
In recent years science has learned that the human immune system is much more complicated than we thought. It is composed of two functional branches or compartments which may work together in a mutually cooperative way or in a mutually antagonistic way depending on the health of the individual.
One branch is the humoral immune system (or Th2 function) which primarily produces antibodies in the blood circulation as a sensing or recognizing function of the immune system to the presence of foreign antigens in the body. The other branch is the cellular or cell-mediated immune system (or Th1 function) which primarily destroys, digests and expels foreign antigens out of the body through the activity of its cells found in the thymus, tonsils, adenoids, spleen, lymph nodes and lymph system throughout the body. This process of destroying, digesting and discharging foreign antigens from the body is known as “the acute inflammatory response” and is often accompanied by the classic signs of inflammation: fever, pain, malaise and discharge of mucus, pus, skin rash or diarrhea.
These two functional branches of the immune system may be compared to the two functions in eating: tasting and recognizing the food on the one hand, and digesting the food and eliminating the food waste on the other hand. In the same way, the humoral or Th2 branch of the immune system “tastes” and recognizes and even remembers foreign antigens and the cellular or Th1 branch of the immune system digests and eliminates the foreign antigens from the body. But just as too much repeated tasting of food will ruin the appetite, so also too much repeated stimulation of the “tasting” humoral immune system by an antigen will inhibit and suppress the digesting and eliminating function of the cellular immune system. In other words, overstimulating antibody production can suppress the acute inflammatory response of the cellular immune system! 1
This explains the polar opposite relationship between acute discharging inflammations on the one hand and allergies and auto-immune inflammations on the other hand. The more a person has of one, the less he or she will have of the other!
A growing number of scientists believe that the increase in America, Europe, Australia and Japan in allergic and auto-immune diseases (which stimulate the humoral or Th2 branch of the immune system) is caused by the lack of stimulation of the cellular or the Th1 branch of the immune system from the lack of acute inflammatory responses and discharges in childhood. 2 3 4 5 We need to identify the factors which cause this shift in the function of the immune system or which cause allergies and auto-immune diseases in childhood to increase!
If we now return to the original question of the mechanism of action of vaccinations, we find what I believe is the key to the puzzle. A vaccination consists of introducing a disease agent or disease antigen into an individual’s body without causing the disease. If the disease agent provoked the whole immune system into action it would cause all the symptoms of the disease! The symptoms of a disease are primarily the symptoms (fever, pain, malaise, loss of function) of the acute inflammatory response to the disease.
So the trick of a vaccination is to stimulate the immune system just enough so that it makes antibodies and “remembers” the disease antigen but not so much that it provokes an acute inflammatory response by the cellular immune system and makes us sick with the disease we’re trying to prevent! Thus a vaccination works by stimulating very much the antibody production (Th2) and by stimulating very little or not at all the digesting and discharging function of the cellular immune system (Th1).
Vaccine antigens are designed to be “unprovocative” or “indigestible” for the cellular immune system (Th1) and highly stimulating for the antibody-mediated humoral immune system (Th2).
Perhaps it is not difficult to see then why the repeated use of vaccinations would tend to shift the functional balance of the immune system toward the antibody-producing side (Th2) and away from the acute inflammatory discharging side (the cell-mediated side or Th1).
This has been confirmed by observation especially in the case of Gulf War Illness: most vaccinations cause a shift in immune function from the Th1 side (acute inflammatory discharging response) to the Th2 side (chronic auto-immune or allergic response). 6 The outcome of this line of thought is that, contrary to previous belief, vaccinations do not strengthen or “boost” the whole immune system. Instead vaccinations overstimulate the “tasting and remembering” function of the antibody-mediated branch of the immune system (Th2) which simultaneously suppresses the cellular immune system (Th1) thus “preventing” the disease in question.
What in reality is prevented is not the disease but the ability of our cellular immune system to manifest, to respond to and to overcome the disease!
There is no system of the human being, from mind to muscles to immune system, which gets stronger through avoiding challenges, but only through overcoming challenges. The wise use of vaccinations would be to use them selectively, and not on a mass scale.
In order for vaccinations to be helpful and not harmful, we must know beforehand in each individual to be vaccinated whether the Th1 function or the Th2 function of the immune system predominates.
In individuals in whom the Th1 function predominates, causing many acute inflammations because the cellular immune system is overreactive, a vaccination could have a balancing effect on the immune system and be helpful for that individual.
In individuals in whom the Th2 function predominates, causing few acute inflammations but rather the tendency to chronic allergic or autoimmune inflammations, a vaccination would cause the Th2 function to predominate even more, aggravating the imbalance of the immune system and harming the health of that individual. This is what happened in Gulf War Illness.
The current use of vaccinations in medicine today is essentially a “shotgun” approach which ignores differences among individuals. In such an approach some individuals may be helped and others may be harmed.
If medicine is to evolve in a healthy direction, we must learn to understand the particular characteristics of each individual and we must learn how to individualize our treatments to be able to heal each unique human being in our care.
Based on the preceding explanation of how vaccinations work, here are my answers to your questions:
Vaccinations are usually effective in preventing an individual from manifesting a particular illness, but they do not improve the overall strength or health of the individual nor of the immune system. Instead, vaccinations modify the reactivity of the immune system, decreasing acute discharging inflammatory reactions and increasing the tendency to chronic allergic and auto-immune reactions.
Epidemiologic studies 7 8 9 have shown that as families improve their living conditions, hygiene, nutrition, literacy and education, the risk of life-threatening acute infectious , inflammatory diseases very much decreases. Families with poor living conditions, hygiene, nutrition and literacy would generally be most likely to benefit from vaccinations.
Families with good living conditions, hygiene, nutrition and education probably would benefit from vaccinations very little or not at all. Individuals with a tendency to allergic or auto-immune diseases are likely to be harmed by vaccinations.
Side effects of vaccination are usually allergic or auto-immune inflammatory reactions caused by the shift of the immune system’s reactivity from the Th1 side to the Th2 side.
Modern medicine is just beginning to recognize this. 10
Modern medicine has not scientifically measured the risk/benefit ratio of any vaccine. 11
Research into the risks of vaccines is very inadequate, according to two comprehensive reports on vaccines by the U.S. Institute of Medicine in 1991 and 1994.
My preceding explanation of how vaccinations affect the immune system is true also in animals. Vaccinations cannot make animals healthier, but only good handling, environment and nutrition can make animals healthy and resistant to disease. Vaccinating pigs may prevent them from having illness from one particular strain of virus but will not improve their overall resistance to other illnesses nor even to other strains of the same virus.
It is important to remember that an infection with a particular virus or bacterium does not necessarily cause illness unless the resistance of the individual is low. In the case of Japanese Encephalitis Virus (JEV), most infections cause no symptoms and fewer than 0.1% of infected individuals develop severe encephalitis. 12 Individuals living in poor conditions, with poor hygiene, nutrition and education are at higher risk of serious illnesses from JEV or any other infection. In such individuals a vaccination would most likely be helpful.
Each individual should inform himself or herself: just how widespread is the disease outbreak? How many have become seriously ill or died? Does the outbreak affect all levels of society or mainly those in poor living conditions?
Very often the media exaggerate the extent of such outbreaks. Each individual should freely decide, based on knowledge and not on fear and hearsay, whether he or she or a child would benefit from a vaccination.
Philip F. Incao, M.D.
1. Parish, C.R. “The Relationship Between Humoral and Cell-Mediated Immunity.” Transplant. Rev. 13 (1972):3.
2.Ronne, T. “Measles Virus Infection without Rash in Childhood is Related to Disease in Adult Life.” The Lancet Ltd. (1985):1-5.
3. Odent, M.R., Culpin, E.E., Kimmel, T. “Pertussis Vaccination and Asthma: Is There a Link The Journal of the American Medical Association 272(1994):588.
4. Cookson, W.O.C.M., and Moffatt, M.F. “Asthma: An Epidemic in the Absence of Infection?” Science 275(1997):41-42.
5. Martinez, F.D. Role of viral infections in the inception of asthma and allergies during childhood: could they be protective? Thorax 1994;49: 1189-91.
6 Rook, G.A.W., Zumla, A. “Gulf War Syndrome: Is It Due to a Systemic Shift in Cytokine Balance Towards a Th2 Profile?” The Lancet 349 (1997):1831-1833.
7. McKeown, T. The Modern Rise of Population. New York: Academic Press, 1976.
8. McKeown, T. The Role Of Medicine: Dream, Mirage, or Nemesis?New Jersey: Princeton University Press 1979.
9. Sagan, L.A. The Health of Nations. New York: Basic Books,Inc., 1987.
10. Rook, G.A.W., Zumla, A. “Gulf War Syndrome: Is It Due to a Systemic Shift in Cytokine Balance Towards a Th2 Profile?” The Lancet 349 (1997):1831-1833.
11. Robin, Eugene, M.D. “Some Hidden Dimensions of the Risk/Benefit Value of Vaccine” from the First International Public Conference on Vaccination. Alexandria, Virginia September
12. Solomon, T., Kneen, R., Dung, N.G., Khanh, V.C., Thuy, T.T.N., Ha, D.Q., Day, N.P.J., Nisalak, A., Vaughn, D.W., White, N.J. “Poliomyelitis-like illness due to Japanese encephalitis virus” Lancet 1998; 351: 1094-97