by Densie Nichols, Staff Writer
Breaking Research news today that I am already circulating widely that I needed to get posted here on VETERANS Today. Dr. Kenny De Meirleir Announces He has Revealed the True Nature of ME/CFS (Myalgic Encephalomyelitis / Chronic Fatigue Syndrome announcement again should give a boost to our gulf war and Desert Storm Veterans. This research highlights the development of yet another breaking science report on biomarkers for the worse cases of Chronic Fatigue Inflammation called more correctly Myalgic Encephalomyelitis.
This is the type of research that will trigger more high level researchers to want to get involved. This illness affects huge numbers of civilians and gulf war veterans in our country. The impact on this nation in terms of loss income for civilians and veterans is huge and doctors have been stumbling because research has been terribly lacking and misdirected.
The civilians have faced the same type stigma of being told it is all in their heads that our gulf war veterans of Operation Desert Storm have faced. They also have been offered research and treatment based on Cognitive Therapy or Exercise that does little good. This type of research could ultimately be tied to more research answers for our ill Desert Storm Veterans with Gulf War Illness.
WE need a "Manhattan Type" Effort in addressing this medical problem. We do not need for sick Gulf War Veterans of Operation Desert Storm recruiting others and going hat in hand to get research money every year from the Appropriations and Authorizations Committees of the House and Senate led by one Senator and one Representative. This medical problem is as important as the AIDS money going to Africa and funds spent on Vaccine Development.
WE need the best and the brightest at the White House to fully recognize the plight of the Desert Storm Veterans with Gulf War illness that has occurred over 18 years and fully fund the recommendations made in the November 2008 Research Advisory Committee on Gulf War illness for DOD CDMRP funding into Gulf War illness. Foot dragging, denial, delay, coverups have to end now.
Mr President Obama many veterans voted for you in a radical change from their previous direction in hopes that a change for the better would happen. Well we are waiting after 100 plus days for clear stated and public written policy from the White House on Gulf War Veterans of Operation Desert Storm sufferring from Gulf War illness and yes dying in their 30’s, 40’s and 50’s. Something did happen in 1990-91 when we went to the Gulf War and we can not wait much longer.
WE need Immediate Actions! We need a landmark decision: grant the claims automatically at some level that veterans can live on while we find the biomarkers and treatment modalities that I believe can happen. Set up the system of Integrative Research to Clinical Practice that I have proposed in conjunction with the outstanding Medical Universities and VA’s COE for Gulf War illness. It is time for outside the box thinking and innovation.
Published at ProHealth today: At 11:00 AM London time on May 28, 2009, ME/CFS researcher Dr. Kenny De Meirleir, MD, PhD, spoke at a press conference unveiling his team’s groundbreaking findings regarding the illness called Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS). The presentation covered the team’s conclusions regarding the complex mechanisms of ME/CFS pathogenesis, a diagnostic test, and directions for therapeutic strategies.
(Dr. De Meirleir, a Belgian scientist known for his cutting edge ME/CFS research, is a professor at the Vrije Universiteit Brussels and Director of HIMMUNITAS Foundation Brussels.)
• A link to slides used in the press conference (accompanying script to come soon, perhaps in a presentation Dr. De Meirlier will give Friday, May 29 at Invest in ME’s International ME/CFS Conference in London)
• The preliminary draft abstract of an upcoming journal article by the De Meirleir research team (“Research on Extremely Disabled M.E. Patients Reveals the True Nature of the Disorder”)
SLIDES USED IN PRESS CONFERENCE
To view the slides Dr. De Meirleir used in his press conference, go to http://www.mefmaction.net/Portals/0/docs//CFSDeMeirleir.pdf.
ABSTRACT OF UPCOMING JOURNAL ARTICLE – Preliminary Draft
The De Meirleir research team will also publish a journal article on their work. The following draft was disseminated via the CO-CURE listserv May 28 by ME research reporter Jan van Roijen ([email protected]).
Research on Extremely Disabled M.E. Patients Reveals the True Nature of the Disorder
By Kenny De Meirleir(1), Chris Roelant(2), Marc Fremont(2), Kristin Metzger(2), Henry Butt(3)
(1) Vrije Universiteit Brussel & HIMMUNITAS foundation, Brussels, Belgium
(2) Protea Biopharma, Brussels, Belgium
(3) Bioscreen & Bio 21, University of Melbourne, Melbourne, Australia
In this study we compared totally bedridden patients (Karnofski score 20-30) with less ill ME patients (Karnofski score 60-70), family controls, contact controls and non-contact controls.
EBV, HHV6 and Borna virus titers were not different in the three groups. Plasma LPS distinguished the groups, with the highest values in the bedridden patients.
LPS [lipopolysaccharide] is a strong activator of the immune system, and high plasma concentrations suggest a hyperpermeable gut. There are many possible causes for this, but a lack of ‘local’ energy production is one of them.
In a separate study (In Vivo, in press) we observed intestinal overgrowth of Gram positive D/L lactate-producing bacteria which are also known to produce H2S [hydrogen sulfide] in presence of certain heavy metals as a survival defense mechanism.
We therefore hypothesized that the urine of the bedridden ME patients would contain more H2S derived metabolites than the less ill and the controls. Using a proprietary simple color change urine test this hypothesis was confirmed.
In the extremely ill, urine added to the yellow color reagent immediately turns dark blue, whereas in the less ill the reaction is slower and in the controls no reaction occurs.
Being a potent neurotoxin, H2S induces photophobia, intolerance to noise,
mitochondrial dysfunction by inhibition of cytochrome oxidase, and depresses the cellular immune system and induces neutropenia and low numbers of CD8+ lymphocytes.
Its effects, at least in part explain the clinical condition of the severely disabled ME patients.
Furthermore the effects of the bacterial H2S induces increased ROS production by the liver and retaining of heavy metals particularly mercury in the body.
The latter is also neurotoxic, induces apoptosis, and interferes with the aerobic metabolism. Chronic increased production of H2S by intestinal bacteria leads to build-up of mercury in the body as proven by a Zn DTPA/DMPS challenge test.
Finally in 20% of the ME patients (in the severely ill) we found, using a special luminescence technique, aberrant prions which also interfere with the energy metabolism.
These patients have gone on to develop A.P.D. (aberrant prion disease – patent pending). These aberrant prions give rise to a transmissible disorder. 10% of the A.P.D. patients have very high prion counts in their saliva and can directly transmit it to others.
APD patients can transmit these proteins via blood and likely also through sexual contact which then can give rise to slowly developing aberrant prion disease.
In a separate experiment 40 healthy blood donors were screened for A.P.D. One individual tested very positive, indicating that apparently healthy individuals can already be carriers and that blood transfusion carries the risk of transmitting A.P.D.
In conclusion, ME is a disorder which is caused by increased endogenous H2S production. For the latter many factors can be present.
Because of the effects of H2S in the body a chain of events will develop which have more and more negative effects on the aerobic metabolism and depression of the immune system leading to more and more infections and reactivation of endogenous viruses.
In its final stage aberrant transmissible prions develop which put the patients in a total energy depleted state.